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January 1, 1977Journal of Medicinal Chemistry

An improved method for O-demethylation of codeine

John A. Lawson Joseph I. DeGraw

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Abstract

The O-demethylation of codeine was effected by sodium propylmercaptide in dimethylformamide at 125 degrees C to afford morphine in 80% yield. Similar treatment of thebaine was unrewarding.

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Lawson et al. (1977) studied this question.

synapsesocial.com/papers/6aa8ce20417c2001158725fe https://doi.org/10.1021/jm00211a037

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