In order to synthesize the series of 2-chloroethylnitrososulfamides (CENS), a procedure using the nucleophilic exchange of an activating group of both the sulfamoyl esters and amides by several amines was developed. The N-oxysuccinimide sulfamate ester was revealed as the most reactive sulfamoyl group donor. This transsulfamoylation procedure allows the preparation of title compounds, especially the derivatives of amino acid esters in two steps in a 75–80% yield.
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Abdaoui et al. (1996) studied this question.
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