An efficient, practical, and stereocontrolled synthesis of 1β‐methylcarbapenems has been performed utilizing a new dehydration type of Ti‐Dieckmann (intramolecular Ti‐Claisen) condensation. This cyclization reaction has the advantage of direct incorporation of the thiol moiety into the target 1β‐methylcarbapenem, compared with the traditional basic Dieckmann condensation. Another advantage is the use of environmentally benign (low toxicity and safe) reagents (TiCl4 and Et3N or Bu3N).
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Tanabe et al. (2003) studied this question.
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