The DNA coding for histone proteins, together with the intervening spacer DNA, has been isolated from the sea urchin, Psammechinus miliaris, by repeated centrifugation on CsCl-asctinomycin gradients. The biophysical data show that a major portion of the spacer is 37% G+C and very divergent in sequence, while the DNA segments coding for histone proteins are high in G+C and have diverged to a lesser extent within the species.
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Birnstiel et al. (1974) studied this question.
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