Granuloma Inguinale

The etiology of granuloma inguinale has interested investigators in this field throughout the world since the disease was first adequately described by Conyers and Daniels in 1896. Donovan created widespread interest in the disease by describing cellular inclusions which were constantly found in smears obtained from cases of granuloma inguinale. The cellular inclusions discovered by Donovan were found in the cystoplasm of the mononuclear cells, which cell is the predominating one of the lesion. Donovan's discovery has been confirmed by all of those investigators who have interested themselves in the study of this disease. The cellular inclusions have been named after their discoverer, and are known as Donovan bodies. A disease that has been established as a definite clinical entity, being widespread in its geographic distribution, portraying the same clinical manifestations, the same pathologic change, the constant observation of the Donovan bodies in smears from the lesion and the organism