The Role of Endotoxin during Typhoid Fever and Tularemia in Man. III. Hyperreactivity to Endotoxin during Infection *

endotoxin tolerance in normal or in convalescent man are not justified.Reactions to endotoxin must be studied in the infected host during the febrile phase of illness.The following studies were performed in man to define a) the effect of induced endotoxin tolerance on the subsequent febrile and clinical course of two gram-negative bacterial infections, typhoid fever and tularemia, and b) the influence of the typhoid and tularemic infections on the preinduced endotoxin tolerance. Materials and MethodsVolunteers for these studies were male inmates of the Maryland House of Correction, Jessup, Md., whose ages ranged from 22 to 44.Each volunteer was fully ap- prised of all aspects of the investigation and the at- tendant risk.They were free to cease participation at any time.Complete medical surveys were performed to verify the fitness of each participant.