Mature male rats were castrated and accessory organs regressed 20 days before X-irradiation and/or hormone treatment. Androgen-treated castrates received daily 500 μg of testosterone propionate in oil, total amount 1500 μg. Animals were sacrificed 60 hours following initial treatment. The mitotic, index with hormone was 8%, whereas following androgen and irradiation at 80, 160, 320 and 640 r it was 14, 20, 17 and 15% respectively. At levels of 1000, 1500, 2000, and 3000 r these values were 5, 4, 3 and 1%. These data indicate inhibition of mitotic activity at levels of 1000 r and above. It is suggested that irradiation between 80 and 640 r caused a delay in mitotic response of secretory epithelium and as a result the mitotic index was greater than in those which received androgen alone. X-irradiation had no significant effect on cell height. There was a decrease in seminal vesicle weights of animals treated with hormone and increasing amounts of irradiation.
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Melampy et al. (1956) studied this question.