First detection of human infection by Cache Valley and Kairi viruses (Orthobunyavirus) in Argentina

Human sera samples from Córdoba Province, Argentina were analyzed by reduction neutralization test for Cache Valley (CVV) and Kairi (KRIV) viruses. A 5.72% (27/472) prevalence of neutralizing antibodies for CVV and 5.92% (31/524) for KRIV was detected in Córdoba City, whereas the prevalences in Jesús María and Colonia Caroya suburban cities was 7.83% (13/166) and 5.42% (9/166) for CVV and KRIV, respectively. The neutralizing antibody titers ranged between 1/20 and >or=1/160. Our results report the first known infection by CVV and KRIV in human inhabitants from temperate areas of Argentina.