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November 1, 2020Diabetes Metabolic Syndrome and ObesityOpen Access

The Beneficial Role of Anchomanes difformis in STZ-Induced Reproductive Dysfunction in Male Wistar Rats

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Authors

TAToyin Dorcas AlabiBaze UniversityCVCharon de VilliersSouth African Medical Research CouncilSPStefan S. du PlessisSouth African Medical Research Council

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Implication

Controlled animal study demonstrates that Anchomanes difformis leaf extract restores sperm parameters and testicular morphology in diabetic male rats, highlighting its therapeutic potential for...

Key Points

  • To assess the efficacy of Anchomanes difformis leaf extract in ameliorating diabetes-induced male reproductive dysfunction and testicular tissue alterations in a rat model.
  • Type 2 diabetes was induced in male Wistar rats via 10% fructose administration for 2 weeks followed by an intraperitoneal injection of 40 mg/kg streptozotocin.
  • Rats were randomized into 7 groups (8 normal rats/group, 10 diabetic rats/group) and administered aqueous leaf extract of A. difformis (200 mg/kg or 400 mg/kg) daily for 6 weeks.
  • Sperm concentration, motility indices, viability, and morphology were analyzed using the CASA-SCA system, accompanied by testicular and epididymal histological assessments.
  • Diabetic rats showed significant reductions in sperm concentration, viability, and motility parameters, alongside a 40% abnormal sperm morphology rate.
  • Treatment with A. difformis significantly increased sperm concentration, enhanced sperm viability, and improved the percentage of morphologically normal spermatozoa relative to diabetic controls.
  • Histological analysis revealed that A. difformis mitigated diabetic testicular damage, notably attenuating vacuolization and loss of the germinal epithelium.

Cite This Study

Alabi et al. (2020) studied this question.

synapsesocial.com/papers/6aa8e1f2266cc8089870ef11https://doi.org/10.2147/dmso.s270783
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