Key result
IV isosorbide dinitrate during open heart surgery linked to ~25% lower PVR and reduced mPAP.
Why the study?
Does intravenous isosorbide dinitrate reduce pulmonary vascular resistance and pulmonary artery pressure in adult patients undergoing open heart surgery?
Does intravenous isosorbide dinitrate reduce pulmonary vascular resistance and pulmonary artery pressure in adult patients undergoing open heart surgery?
Answers are grounded in this paper and cite their sources.
Intravenous isosorbide dinitrate acutely reduces pulmonary vascular resistance and pulmonary artery pressure during open heart surgery without affecting systemic pressures or cardiac index, potentially benefiting right ventricular dysfunction.
The acute effects of intravenous isosorbide dinitrate during open heart surgery were studied in 15 adult patients. Consistent and significant (p less than 0.001) reductions in pulmonary vascular resistance (25% before, 23% after, cardiopulmonary bypass) and mean pulmonary artery pressure (14% before, 13% after, cardiopulmonary bypass) were observed in the absence of significant changes in cardiac index, mean systemic arterial pressures or right or left atrial filling pressures. These findings indicate that after cardiopulmonary bypass, when right ventricular dysfunction with raised pulmonary vascular resistance may occur, selective reduction of right ventricular afterload with isosorbide dinitrate may prove beneficial.
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PARSONS et al. (1987) studied Open heart surgery (n=15). Intravenous isosorbide dinitrate was evaluated on Pulmonary vascular resistance and mean pulmonary artery pressure (p=<0.001). Intravenous isosorbide dinitrate during open heart surgery significantly reduced pulmonary vascular resistance by up to 25% and mean pulmonary artery pressure by up to 14% (p<0.001).
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