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A ratiometric fluorescent probe Cy-NEt2 for detecting ONOO- is designed and prepared by de novo synthesis, which is a reliable, cheap and flexible route. The probe is applied for monitoring the level of mitochondrial ONOO- and assessing the lipopolysaccharide (LPS)-induced mitochondrial oxidative stress status in living cells and in vivo successfully.
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Zhou et al. (2018) studied this question.
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