Key result
Arteriograph correlates with Complior and SphygmoCor but wide agreement limits prevent device interchangeability.
Why the study?
Does the Arteriograph oscillometric device provide interchangeable measurements of arterial stiffness compared to standard Complior and SphygmoCor techniques in untreated hypertensive patients?
Cross-Sectional (n=254)
Does the Arteriograph oscillometric device provide interchangeable measurements of arterial stiffness compared to standard Complior and SphygmoCor techniques in untreated hypertensive patients?
Effect estimate: r = 0.60 (PWV) and r = 0.89 (AIx)
p-value: p=<0.001
Although the Arteriograph oscillometric device correlates with standard tonometric and piezo-electronic techniques for measuring arterial stiffness, wide limits of agreement mean the devices cannot be used interchangeably.
Arteriograph correlates with Complior and SphygmoCor but techniques are not interchangeable; leaves open routine adoption pending further validation in hypertension.
Arterial stiffness, measured as aortic pulse wave velocity (PWV), and wave reflection, measured as augmentation index (AIx) are independent predictors, for total and cardiovascular morbidity and mortality. The aim of this study was to compare a new device, based on oscillometric pressure curves (Arteriograph) which simultaneously measures PWV and AIx to standard techniques for measuring PWV (Complior) and AIx (SphygmoCor) in untreated hypertensive subjects. We compared PWV and AIx measured using the Arteriograph with corresponding Complior and SphygmoCor measurements in 254 untreated hypertensive patients, age 48±14 (mean±SD) [17 to 85 years]. Arteriograph PWV and AIx were closely related with Complior (r=0.60, P<0.001), and SphygmoCor (r=0.89, P<0.001) respectively. Using stepwise regression analysis, the independent determinants of Arteriograph PWV were age, mean arterial pressure (MAP), heart rate (HR) and gender (R2=0.44p<0.0001) and for AIx; age, weight, MAP, HR and gender (R2=0.65, p<0.0001). The bias between the different techniques was determined by age and gender for PWV and age, body weight, gender, HR and MAP for AIx. Bland-Altman Plots showed that while the techniques were closely related, the limits of agreement were wide. While Arteriograph values and the determinants of PWV and AIx are in close agreement with corresponding parameters obtained by Complior and SphygmoCor respectively, the techniques are not interchangeable.
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Mahmud et al. (2009) conducted a cross-sectional in Hypertension (n=254). Arteriograph vs. Complior and SphygmoCor was evaluated on Correlation of pulse wave velocity (PWV) and augmentation index (AIx) (r = 0.60 (PWV) and r = 0.89 (AIx), p=<0.001). Arteriograph measurements of arterial stiffness correlated with Complior (r=0.60) and SphygmoCor (r=0.89), but wide limits of agreement indicate the techniques are not interchangeable.
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