Answers are grounded in this paper and cite their sources.
In this work, a particular electrochemical sensor for analysis of isoniazid (INZ), a tuberculostatic drug, was presented. The electrotreated pencil graphite electrode (ETPGE) was modified by a nanocomposite of the copper-based metal-organic frameworks (Cu-MOFs)/carbon nitride quantum dots (CNQDs), Cu-MOFs/CNQDs/ETPGE, and was utilized for electroanalysis of INZ. Physicochemical characteristics and analytical performance of the Cu-MOFs/CNQDs/ETPGE were investigated through relevant instruments. Compared with bare PGE, ETPGE, CNQDs/ETPGE, and Cu-MOFs/ETPGE, the Cu-MOFs/CNQDs/ETPGE showed strong electrocatalytic activity for oxidation of the INZ and exhibited a well-defined anodic peak at a low potential of +0.364 V versus Ag/AgCl in pH 7.0 medium due to its high specific surface area, high conductivity and fast charge transfer ability. The experimental results demonstrated that the Cu-MOFs/CNQDs/ETPGE has a promising potential candidate as a stable and efficient electrochemical sensor for determination of INZ. Under the optimized experimental conditions, the designed sensor presented a wide linear response range for INZ concentration (0.1 μM to 65.0 μM) with a low practical detection limit (0.0675 μM), limit of quantification (LOQ) (0.225 μM), high sensitivity (1.507 A mol−1 L cm−2) and excellent repeatability in differential pulse voltammetry. Further, the suggested method was employed successfully for determination of INZ in drug and biological samples with satisfactory recovery values.
No takes yet. Share an insight, caveat, or question.
Pashazadeh et al. (2020) studied this question.