Key result
Familial hypercholesterolemia requires early cascade screening and optimal LDL control to prevent premature cardiovascular disease.
Why the study?
Familial hypercholesterolemia is a common genetic cause of premature cardiovascular disease, but it remains frequently underdiagnosed or inappropriately treated.
Early recognition and optimal control of LDL levels through a multi-disciplinary approach are crucial in preventing the atherosclerotic burden of familial hypercholesterolemia.
Early FH recognition may curb premature CVD; leaves open prospective validation of novel LDL therapies.
Familial hypercholesterolemia is an important cause of premature cardiovascular disease.A defect in low-density lipoprotein (LDL) metabolism results in extremely elevated levels of LDL-cholesterol.Although it was one of the most common genetic disorders, it is frequently underdiagnosed or inappropriately treated.Current advances in LDL lowering therapies have made a great promise in treating familial hypercholesterolemia. Early recognition and optimal control of LDL levels are crucial in preventing its atherosclerotic burden.A multi-disciplinary approach is needed to provide optimal care for patients with familial hypercholesterolemia.In this clinical paper, we outline the current knowledge about screening, diagnosis, and management of familial hypercholesterolemia.
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Yousif M. Hydoub (2019) conducted a review in Familial hypercholesterolemia. Familial hypercholesterolemia is an important cause of premature cardiovascular disease that requires early recognition, cascade screening, and optimal control of LDL levels to prevent atherosclerotic burden.
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