Four C-geranyl flavonoids from the flowers of Paulownia fortunei and their anti-inflammatory activity

Four new C-geranyl flavonoids, paulownione D-G (1–4) were isolated from the 50% acetone-H2O extract of the flowers of Paulownia fortunei. The structures of the compounds were determined by extensive spectroscopic analyses (UV, IR, HR-ESI-MS, 1D and 2D NMR). All of the compounds (1–4) exhibited potent protection effects in H9c2 cardiocytes against the lipopolysaccharide (LPS)-induced inflammation.