Performance of the BioPlex 2200 Multiplexing Immunoassay Platform for the Detection of Herpes Simplex Virus Type 2 Specific Antibodies in African Settings

Jérôme LeGoff; Gérard Grésenguet; Chrysostome Gody; Jean De Dieu Longo; Nzambi Khonde; Helen A. Weiss; Philippe Mayaud; Laurent Bélec

doi:10.1128/cvi.05003-11

May 11, 2011Clinical and Vaccine ImmunologyOpen Access

Performance of the BioPlex 2200 Multiplexing Immunoassay Platform for the Detection of Herpes Simplex Virus Type 2 Specific Antibodies in African Settings

View Full Paper

Ask AI

Bookmark

Share

Key Points

To evaluate the performance of the BioPlex 2200 multiplex immunoassay platform for detecting herpes simplex virus type 2 (HSV-2) antibodies in sub-Saharan African individuals against clinicovirological standards and HerpeSelect.
Evaluated the BioPlex 2200 platform for HSV-2 antibody detection in sub-Saharan African individuals in comparison to clinicovirological reference standards.
Compared diagnostic sensitivity, specificity, and concordant results directly against the HerpeSelect assay.
BioPlex demonstrated a diagnostic sensitivity of 88.9% and a specificity of 93.5% relative to reference standards.
HerpeSelect demonstrated a sensitivity of 89.9% and a specificity of 92.7%.
Overall concordance between the BioPlex platform and HerpeSelect was 95.7%.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Abstract

The BioPlex platform was evaluated for the detection of herpes simplex virus 2 (HSV-2) antibodies in sub-Saharan Africa individuals in comparison to clinicovirological standards and compared to HerpeSelect. The sensitivities and specificities were, respectively, 88.9% and 93.5% for BioPlex and 89.9% and 92.7% for HerpeSelect. The agreement between both assays was 95.7%.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

LeGoff et al. (2011) studied this question.

synapsesocial.com/papers/6aa8e9a8b7c808b8b5d91a7f https://doi.org/10.1128/cvi.05003-11

View Full Paper

Ask AI

Bookmark

Share

Performance of the BioPlex 2200 Multiplexing Immunoassay Platform for the Detection of Herpes Simplex Virus Type 2 Specific Antibodies in African Settings

Key Points

Ask about this paper

Abstract

Discussion

Cite This Study

Performance of the BioPlex 2200 Multiplexing Immunoassay Platform for the Detection of Herpes Simplex Virus Type 2 Specific Antibodies in African Settings

Key Points

Ask about this paper

Abstract

Discussion

Cite This Study

Keep reading

Keep reading