Key result
Lung biopsy establishes Enterovirus D68 as a cause of chronic bronchiolitis and progressive respiratory insufficiency.
Why the study?
Chronic bronchiolitis has not been previously attributed to Enterovirus D68 despite its emergence as a cause of epidemic viral bronchiolitis and pneumonia.
Case Report (n=1)
No
This case report provides the first evidence attributing chronic bronchiolitis to Enterovirus D68 in a young adult.
May link EV-D68 to adult chronic bronchiolitis; hypothesis-generating and requires validation before clinical consideration.
Human enteroviruses are less well-known causes of acute bronchiolitis. In recent years, Enterovirus D68 [EV D68] has emerged as significant cause of epidemic viral bronchiolitis and pneumonia in the United States and other countries. Chronic bronchiolitis has not been previously attributed to EV D68. We documented EV D68 in open lung biopsies of a young adult patient who was frequently admitted to the hospital for severe exacerbation of respiratory infections and subsequently developed progressive respiratory insufficiency. The difficulty of diagnosis and potential economic impact of this illness is discussed.
No takes yet. Share an insight, caveat, or question.
Chia et al. (2016) conducted a case report in Chronic Enterovirus D68 Bronchiolitis (n=1). Enterovirus D68 was evaluated on Pathological and virological confirmation of chronic EV D68 bronchiolitis. Enterovirus D68 was documented in open lung biopsies of a young adult patient, establishing it as a cause of chronic bronchiolitis and progressive respiratory insufficiency.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: