The effect of triethylenethiophosphoramide on fifty patients with incurable neoplastic diseases

RIETHYLENETHIOPHOSPHORAMIDE (TSPA), T like triethylenemelamine (TEM) and triethylenephosphoramide ( ~E P A ) , is a member of the class of compounds known as the ethyleneimines.Similarities in chemical structure and biological behavior exist among the different ethyleneimines.'I'SPA is a colorless crystalline compound soluble in water at room temperature.Saline solutions of this compound niay be kept for one week at 5" C.j T h e chemical configuration of TSPA is given in Fig. 1.This compound inhibits the growth of a number ot tumors in mice arid r a t ~. ~-~! lo, 12-14 These tumors are listed in Table 1.Clinical reports on the use of TSPA indicate that this compound has a beneficial effect on certain incurable neoplastic diseases in man.1-4, 9 -1 1 3 1 5 ! 1 G , 2 0 , 2 1 Shay et al. treated with TSPA a series of patients with various neoplastic diseases.g--l1720-T h e best results were obtained in chronic myelogenous leukemia, chronic lymphatic leukemia, and carcinoma of the breast.Improvement also occurred in a few patients with acute leukemia, Hodgkin's disease, lymphosarcoma, multiple myeloma, carcinoma of the ovary, carcinoma of the stomach, and marlom the