Subacute cutaneous lupus erythematosus associated with interferon beta-1a

Interferons, especially interferon alpha, have been associated with the induction or exacerbation of autoimmune and inflammatory disorders, including systemic lupus erythematosus (LE), rheumatoid-like arthritis, bone-marrow aplasia, and glomerulonephritis, as well as autoimmune thyroiditis, hepatitis, thrombocytopenia, and anaemia. 1 Vial T Descotes J Immune-mediated side-effects of cytokines in humans. Toxicology. 1995; 105: 31-57 Crossref PubMed Scopus (154) Google Scholar We report a case of subacute cutaneous LE associated with recombinant human interferon beta-1a.