Use of Dyes with Rapid Bloodstream Clearance for Serial Determination of Cardiac Output

Bloodstream clearance rates and spectral absorption curves of 38 blue dyes have been investigated. The results suggest that suitable dyes for frequent serial estimation of the cardiac output are Patent Blue A, Brilliant Blue, and Patent Blue V. These dyes leave the bloodstream rapidly after injection; they have an adequate build-up of concentration during the first minute: and their maximum spectral absorption occurs at wave lengths of 630 mμ or higher. Cardiac output values obtained in dogs with Patent Blue A, Brilliant Blue, Patent Blue V, and T-1824 dyes are presented and compared.