A series of unprotected pseudo‐disaccharides and pseudo‐trisaccharides of 2‐deoxystreptamine‐containing aminoglycosides have been selectively acylated at the N‐1 position with the valuable (S)‐4‐amino‐2‐hydroxybutanoyl (AHB) pharmacophore by using the recombinant BtrH and BtrG enzymes from butirosin biosynthesis in combination with a synthetic acyl donor. The process was optimized by performing two enzymatic steps in a sequential manner without purification of the intermediate product.
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Nudelman et al. (2008) studied this question.
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