Abstract:In order to study the interspecies variations in small intestinal and hepatic drug metabolism, the benzpyrene hydroxylase and UDP glucuronyl‐transferase activities were determined in the cat, guinea pig, mouse, rabbit and rat. The cat exhibited very low benzpyrene hydroxylase and UDP glucuronyl‐tranferase activities both in its liver and small intestine. Of the other species the guinea pig had the highest benzpyrene hydroxylase activity, the rabbit an intermediate and the rat and mouse the lowest activity in the small intestine. The hydroxylation of 3,4‐benzpyrene by liver microsomes was most active in the mouse and guinea pig, the rat liver showed an intermediate activity and the rabbit liver was least active. The UDP glucuronyl‐transferase activity was highest in the small intestinal mucosa of the rabbit and rat, whereas the guinea pig and mouse exhibited an 80 per cent lower activity. The guinea pig liver microsomes showed the highest activity and the mouse, rabbit and rat livers had an intermediate activity. The rat small intestinal benzpyrene hydroxylase activity could be enhanced to the same level as in the guinea pig by feeding the rats with a guinea pig diet.
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Hietanen et al. (1973) studied this question.
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