Key result
Intrathecal magnesium added to bupivacaine prolongs postoperative analgesia by ~45% but delays block onset.
Why the study?
The effect of adding intrathecal magnesium sulphate to hyperbaric bupivacaine on spinal anaesthesia for lower abdominal surgeries was investigated to evaluate its impact on analgesia duration and block characteristics.
Does the addition of intrathecal magnesium sulphate to bupivacaine prolong the duration of analgesia in adult patients undergoing lower abdominal surgeries?
RCT (n=60)
Double-blind
randomized
Does the addition of intrathecal magnesium sulphate to bupivacaine prolong the duration of analgesia in adult patients undergoing lower abdominal surgeries?
The addition of intrathecal magnesium sulphate to bupivacaine for spinal anesthesia delays the onset of sensory and motor blockade but significantly prolongs the duration of postoperative analgesia.
Prolongs analgesia after lower abdominal surgery despite delayed onset; supports intrathecal magnesium as spinal adjunct.
BACKGROUND is a noncompetitive blocker of N-Methyl-D-Aspartate (NMDA) receptor with anti-nociceptive effects. Recently it has popularity as an adjuvant in spinal anaesthesia. The addition of intrathecal magnesium sulphate to hyperbaric prolongs the duration of analgesia. In this prospective, randomized, double-blind study, we investigated the effect adding intrathecal magnesium sulphate to bupivacaine in spinal anaesthesia for lower abdominal surgeries. AND METHODS ASA I or II adult patients of either sex undergoing lower abdominal surgeries were recruited. They were randomly allocated two groups- Group M received intrathecal 15 mg bupivacaine (0.5% hyperbaric solution) combined with 0.5 mL of 10% 4; Group B received 15 mg bupivacaine (0.5% hyperbaric solution) combined with 0.5 mL of normal saline. We evaluated onset of sensory and motor block, the duration of sensory and motor blockade and duration of spinal anaesthesia. of sensory and motor block was significantly shorter in Group B (2.06±0.79, 3.03±0.65 min) than Group M (4.84±2.24, 7.38±1.14 min).The duration of sensory block was significantly higher in Group M (220.78±9.4 min) than in Group B (165.78±17.6) The mean duration for complete motor recovery was maximum in Group M (271.44±34.72 min) than in Group (180±18.41 min). Duration of analgesia was also longer in Group M (340.62±15.4 min) than with Group B (234.6±27.14 min) was statistically significant (P<0.05). patients undergoing lower abdominal surgery, the addition of intrathecal magnesium sulphate to spinal anaesthesia induced bupivacaine delayed the onset of both sensory and motor blockade, but improved the quality and the duration of analgesia.
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Anshu et al. (2018) conducted an RCT in Lower abdominal surgeries (n=60). Intrathecal magnesium sulphate vs. 0.5 mL of normal saline added to 15 mg bupivacaine (0.5% hyperbaric solution) was evaluated on Duration of analgesia (p=<0.05). Adding intrathecal magnesium sulphate to bupivacaine delayed block onset but prolonged the duration of postoperative analgesia (340.62 vs 234.6 min; P<0.05).
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