Key result
Norovirus RNA was detected in 42.8% (6 of 14) of 8-12-week-old cats with enteritis from a New York shelter, leading to the discovery and genomic characterization of a novel feline norovirus.
Why the study?
The host range of noroviruses in domestic cats and their potential pathogenic role were not well understood.
Observational (n=24)
Yes
Norovirus (NoV) RNA was detected in the stools of 6 out 14 (42.8%) 8-12-week-old cats with enteritis from a feline shelter, in New York State. Upon sequence analysis of the complete capsid, the six NoVs were found to be identical, suggesting the spread of a unique NoV strain in the shelter. The full-length genomic sequence (7839 nt) of one feline NoV, CU081210E/2010/US, was determined. In the capsid protein VP1 region, the virus displayed the highest amino acid identity to animal genogroup IV genotype 2 (GIV.2) NoVs: lion/Pistoia-387/06/IT (97.9%) and dog/Bari-170/07/IT (90.4%). These findings document the discovery of a novel feline calicivirus, different from vesiviruses, and extend the spectrum of NoV host range. Epidemiological studies using feline NoV-specific diagnostic tools and experimental infection of cats are required to understand whether NoVs have a pathogenic role in this species.
No takes yet. Share an insight, caveat, or question.
Pinto et al. (2012) conducted an observational in Gastroenteritis (n=24). Norovirus infection was evaluated on Detection of Norovirus RNA in stools. Norovirus RNA was detected in 42.8% (6 of 14) of 8-12-week-old cats with enteritis from a New York shelter, leading to the discovery and genomic characterization of a novel feline norovirus.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: