Summary: A chitosan‐hydroxybenzotriazole (HOBt) aqueous solution prepared by simply mixing chitosan and HOBt in water provides an effective system to functionalize chitosan in an aqueous environment. This aqueous solution in combination with water‐soluble carbodiimide (WSC) allows the conjugation of functional groups onto chitosan under mild conditions without requiring any organic solvents or acid and heat. In this contribution, a series of model reactions that use a novel water‐based system of chitosan to functionalize the polymer with boc‐L‐phenylalanine, poly(ethylene glycol) methyl ether, and dicarboxylated poly(ethylene glycol) is demonstrated. Chitosan‐HOBt is effectively conjugated with R‐COOH via a water‐soluble carbodiimide (WSC) conjugating agent. magnified image Chitosan‐HOBt is effectively conjugated with R‐COOH via a water‐soluble carbodiimide (WSC) conjugating agent.
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Fangkangwanwong et al. (2006) studied this question.
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