Key result
AF linked to ~48% higher 5-year mortality than expected in women, but not men.
Why the study?
Does atrial fibrillation increase 5-year mortality in men and women compared to the general population?
Cohort (n=129)
No
Does atrial fibrillation increase 5-year mortality in men and women compared to the general population?
Atrial fibrillation is associated with excess 5-year mortality in women but not in men, with levothyroxine treatment and diabetes as significant predictors of death in women.
AF excess mortality limited to women; hypothesis-generating for sex-specific AF risk models and prospective validation.
OBJECTIVE: Five-year mortality in men and women with atrial fibrillation (AF). DESIGN: A follow-up of the medical records of patients with AF registered on September 30, 1993. SETTING: One community health centre in Stockholm County. SUBJECTS: 129 patients (76 men and 53 women). MAIN OUTCOME MEASURES: Observed and expected, age- and sex-standardised, 5-year mortality rates. Significant risk factors by multiple logistic regression. RESULTS: Women had a higher mean age (77.5 vs 72.8 years) and more often suffered from heart failure and hypothyreosis. Five-year mortality rate for men was 30% vs expected 27% in Sweden and 24% in the community; for women it was 43% vs expected 29% (p <0.05) and 23% in the community (p < 0.001), i.e. an excess mortality of 49% and 88%, respectively. Significant factors predicting death by logistic regression among women were: age (odds ratio 1.39, p < 0.001), levothyroxine treatment (odds ratio 27.87, p < 0.05) and diabetes (odds ratio 20.75, p < 0.05). CONCLUSIONS: AF is related to an excess sex- and age-standardised, 5-year mortality in women but not in men, with levothyroxine treatment as one significant factor.
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Per Wändell (2001) conducted a cohort in Atrial fibrillation (n=129). Atrial fibrillation vs. Expected general population was evaluated on 5-year mortality (p=<0.05). Atrial fibrillation was associated with significantly higher 5-year mortality in women compared to expected population rates (43% vs 29%, p<0.05), but no significant excess mortality was observed in men.
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