Key result
Three analytical methods including HPLC successfully identify and quantify sodium azumolene.
Why the study?
No analytical method for sodium azumolene raw material or dosage form has been published so far, despite its potential as a drug to treat malignant hyperthermia.
The study successfully developed and validated new analytical methods for the identification and quantification of sodium azumolene, a highly water-soluble potential treatment for malignant hyperthermia.
Enables precise sodium azumolene quantification in research; leaves open any therapeutic role in malignant hyperthermia.
Sodium azumolene is a drug designed to fight Malignant Hyperthermia (MH), which is characterized by genetic predisposition and triggered by the use of inhalational anesthetics. This drug is shown as a water-soluble analogue of dantrolene sodium, 30-folds more water soluble, which gives advantages for its emergency use. To our knowledge there is no analytical method for sodium zaumolene raw material or dosage form published so far. The objective of the present investigation was to develop and validate analytical methods to achieve sodium azumolene chemical identification and quantification. The sodium azumolene was characterized regarding its thermal behavior, by differential thermal analysis and thermogravimetric analysis; Visible, UV and infrared absorption. To accurately assess the sodium Azumolene content three different analytical methods (visible and UV spectrophotometry and high performance liquid chromatography) were developed and validated. All methods showed to be linear, accurate, precise and reliable. Azumolene has shown to be equipotent to dantrolene in the treatment and prevention of an MH crisis and the great advantage compared to dantrolene is better water solubility. This study has characterized the sodium azumolene and presents new analytical methods which have not been reported so far.
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Josilene Chaves Ruela Corrêa (2014) studied Malignant Hyperthermia. Sodium azumolene vs. Dantrolene sodium was evaluated on Analytical method development and validation for chemical identification and quantification. Three different analytical methods (visible and UV spectrophotometry and HPLC) were successfully developed and validated for the chemical identification and quantification of sodium azumolene.
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