Key result
Healthy females show ~33 ms higher myocardial T1 and greater ECV than males on 3T MRI.
Why the study?
Although T1 and ECV correlate with myocardial fibrosis, their normal values at 3 Tesla MRI and relationship with age and gender needed clarification in healthy adults.
What are the normal T1 and ECV values in healthy adults on 3T MRI, and how do they vary by age and gender?
Cross-Sectional (n=87)
No
What are the normal T1 and ECV values in healthy adults on 3T MRI, and how do they vary by age and gender?
Absolute Event Rate: 1274% vs 1241%
p-value: p=0.003
This study establishes normal reference values for myocardial T1 and ECV on 3T MRI in healthy adults, highlighting significant gender differences that should be considered in clinical assessments.
Abstract purposeThe correlation between T1 and ECV value and myocardial fibrosis has been confirmed. In healthy adult, many disease may change T1 and ECV value. The purpose of this reseach is to clarify the T1 mapping and extracellular volume (ECV) value of healthy adults in 3 Tesla (T) magnetic resonance imaging (MRI), and to study the relationship between the values with age and gender.Methods We recruited 87 healthy adult subjects (mean age 38 ± 11 years; 61% were females) for cardiac magnetic resonance examination at 3T MRI. The left ventricular function parameters were obtained from functional imaging. T1 mapping was performed using an improved Look-Locker reversal recovery sequence after motion correction. resultsUnder 3T field strength, T1 value of the myocardium of healthy adults was 1,261 ± 52, and the ECV value was 28.3% ± 2.9%. T1 value and ECV values of female myocardium were higher than those of males (1,274 ± 56 vs. 1,241 ± 40, P = 0.003; 29.6% ± 2.6% vs. 26.2% ± 2.1%, P < 0.001). Only gender (Beta = 0.311, P = 0.003) was independently related to the native T1 mapping of left ventricular myocardium, while gender (Beta = 0.572, P < 0.001) and age (Beta = 0.501, P = 0.003) were related to the ECV value of left ventricular myocardium. T1 value (P = 0.002) and ECV value (P = 0.013) increased significantly from the base to the apex. There were significant differences in the T1 and ECV value between each segment (P < 0.001) in the base of the left ventricle. Significant differences were observed between the middle segments of T1 value (P = 0.001) but not between the middle of the ECV value of each segment (P = 0.068). Lastly, there was no statistical difference between each segment in the apical of the T1 (P = 0.756) and ECV value (P = 0.344).ConclusionsUnder 3T MRI, the T1 value of the myocardium of healthy adults was 1,261 ± 52, and the ECV value was 28.3% ± 2.9%. T1 and ECV values of females were significantly higher than those of males. The ECV values of males increased with age, while T1 value in males and T1 and ECV values in females had no significant relationship with age.
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Huang et al. (2021) conducted a cross-sectional in Healthy adults (n=87). Female gender vs. Male gender was evaluated on Native myocardial T1 value (ms) (p=0.003). In healthy adults undergoing 3T MRI, myocardial T1 and ECV values were significantly higher in females compared to males (1,274 vs 1,241 ms, P=0.003; 29.6% vs 26.2%, P<0.001).
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