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September 1, 1977Antimicrobial Agents and ChemotherapyOpen Access

Biotransformation of Sisomicin to Gentamicin C 2b

B. K. Lee Janet V. Bailey R. G. Condon JOSEPH A. MARQUEZ Gerald H. Wagman Marvin Weinstein

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Abstract

Sisomicin was transformed to gentamicin C(2b) by Micromonospora rhodorangea NRRL 5326. The mechanisms involved in the biotransformation are the 6'-N-methylation and the (4'-5')-reduction. The progression of the methylation was followed by the isotope technique, but the reduction reaction was not monitored.

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Lee et al. (1977) studied this question.

synapsesocial.com/papers/6aa90449f153b06b0dd91d3f https://doi.org/10.1128/aac.12.3.335

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