A dose of 1 g of riboflavine caused a large excretion of the vitamin in human urine and the rate of excretion showed more than one maximum. 2. Various degradation products of riboflavine appeared in the urine approximately 24 h after the dose was administered and two of these were identified as 7,8-dimethyl-10-(2-hydroxy-ethyl)isoalloxazine, and 7,8-dimethyl-10-formyl-methylisoalloxazine. Reasons are given for believing that the degradation of riboflavine was due to bacterial action in the colon.
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West et al. (1969) studied this question.
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