Polyurethane Microspheres as Drug Carriers

Polyurethane microspheres were prepared by reacting polyethylene glycol [PEG] (of different molecular weights) with different mole ratios of tolylene diisocyanate. A conventional drug was incorporated into the microspheres. The polyurethane microspheres were characterized by FTIR, optical microscopy and particle size analysis. The equilibrium fluid content of microspheres was determined in suitable buffer media. The release pattern of the drug entrapped inside the microspheres was monitored using a UV-VIS spectrophotometer.