Prolactinoma in an Adolescent Girl: Unusual Response to Bromocriptine Therapy

Sir.—Although pituitary tumors have been reported in young children,1prolactinoma in young girls is rare. The youngest described patient, to my knowledge, was a 13-year-old girl.2With bromocriptine mesylate therapy, the symptoms of patients with prolactinoma improve and the prolactin level normalizes or is greatly reduced.2-4Herein, I describe another adolescent girl with prolactinoma, who showed a dissociation of response to bromocriptine, resumption of menses and cessation of galactorrhea, and continued elevation of prolactin levels. Patient Report.—A 15-year-old black girl with cessation of menses for 1 year and galactorrhea for 6 months was referred to the pediatric endocrine clinic of the Walter Reed Army Medical Center, Washington DC, on July 31, 1979. Born July 12, 1964, her growth and development had been unremarkable. Menarche occurred at the age of 13 years (July 1977). Regular menses continued until December 1977 when it became scanty and infrequent and