The sodium form of purified Chelex‐100 can be used to remove trace metals from artificial and natural seawater without altering the major cation‐anion composition or contributing organic toxicants or chelators. Specific contaminant trace metals, often present in artificial seawater at toxic levels, are reduced to levels that permit the growth of sensitive marine phytoplankton and the development of certain invertebrates from the egg through early larval stages. The concentrations of essential trace metals are reduced below the nutritional requirements of selected species of marine phytoplankton.
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Davey et al. (1970) studied this question.