Tailoring biological treatment: anakinra treatment of posterior uveitis associated with the CINCA syndrome

Tailoring biological treatment: anakinra treatment of posterior uveitis associated with the CINCA syndrome Chronic infantile neurological cutaneous articular (CINCA) syndrome, also known as neonatalonset multisystem inflammatory disease, is a rare congenital inflammatory disease characterised by cardinal signs including a variable congenital maculopapular urticarial rash, chronic non-inflammatory arthropathy with abnormal cartilage proliferation, and chronic meningitis with progressive neurological impairment associated with polymorphonuclear and occasionally eosinophilic infiltration. 1The CINCA syndrome is associated with childhood uveitis and papillitis with chronic disc swelling. 2][8][9][10] We report the case of successful treatment with rHuIL1Ra of a patient with refractory CINCA-associated uveitis.