Comparison of Negative Pressure Wound Therapy Using Vacuum-Assisted Closure With Advanced Moist Wound Therapy in the Treatment of Diabetic Foot Ulcers: a Multicenter Randomized Controlled Trial

We appreciate Dr. Hemkens and Dr. Waltering's (1) comments on our recently published article on the use of negative pressure wound therapy (NPWT) as delivered by vacuum-assisted closure therapy in the treatment of diabetic foot ulcers (2). We thank Hemkens and Waltering for recognizing the difficulty in conducting this randomized clinical trial in a blinded fashion. However, we did insure that therapy selection was conducted in a blinded fashion. Neither the physician nor the patient was aware of the treatment assignment before enrolling. Hemkins and Waltering also state that there was a high proportion of censored subject data (33%, n = 11). Given age, health …