Mitochondrial Dysfunction across Synovial and Peripheral Compartments in Rheumatoid Arthritis: A Multi-tissue Transcriptomic Integration of PBMC, Synovial Biopsy and Whole Blood

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Integrative transcriptomic analysis reveals shared and tissue-specific molecular signatures of mitochondrial dysfunction across peripheral blood mononuclear cells, synovial biopsies, and whole blood in rheumatoid arthritis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Sevinç Akçay

doi:10.34248/bsengineering.1964431

September 14, 2026Black Sea Journal of Engineering and ScienceOpen Access

Mitochondrial Dysfunction across Synovial and Peripheral Compartments in Rheumatoid Arthritis: A Multi-tissue Transcriptomic Integration of PBMC, Synovial Biopsy and Whole Blood

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Key Points

Identify shared and tissue-specific transcriptomic signatures of mitochondrial dysfunction across synovial and peripheral compartments in rheumatoid arthritis.
Conducted an integrative transcriptomic analysis using three public datasets: GSE17755 (PBMC), GSE89408 (synovial biopsy), and GSE93272 (whole blood).
Evaluated differentially expressed genes across peripheral blood mononuclear cells, whole blood, and synovial joint tissue to identify overlapping mitochondrial pathways.
Demonstrated differential expression of mitochondrial genes across both peripheral immune cells and synovial tissue compartments.
Identified shared as well as tissue-specific transcriptomic alterations linked to mitochondrial dysfunction across systemic and localized sites in rheumatoid arthritis.

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Implication

Integrative transcriptomic analysis reveals shared mitochondrial dysfunction signatures across peripheral blood and synovial tissue in rheumatoid arthritis, highlighting systemic metabolic disruption.

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Sevinç Akçay (2026) studied this question.

synapsesocial.com/papers/6aa9134b9013453be30a11c1 https://doi.org/10.34248/bsengineering.1964431

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Mitochondrial Dysfunction across Synovial and Peripheral Compartments in Rheumatoid Arthritis: A Multi-tissue Transcriptomic Integration of PBMC, Synovial Biopsy and Whole Blood

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Mitochondrial Dysfunction across Synovial and Peripheral Compartments in Rheumatoid Arthritis: A Multi-tissue Transcriptomic Integration of PBMC, Synovial Biopsy and Whole Blood

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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