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Review demonstrates sustained antipsychotic therapy reduces mortality, cardiovascular risk, and cognitive decline in severe mental illness, highlighting the need to reframe treatment as medical care.
Antipsychotic non-adherence, driven partly by stigma, worsens outcomes in severe mental illness. Beyond ameliorating psychosis, evidence shows sustained antipsychotic treatment reduces mortality, cardiovascular risk, suicide, inflammation and cognitive decline, while improving quality of life. Reframing antipsychotics as essential medical care may reduce stigma and improve engagement with patients and clinicians.
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Dratcu et al. (2026) studied this question.
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