Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“Prescribers in mental health are often taught how to start medicines but not how to end them, or how to recognize an endpoint.”
“The medication may be partially effective but still have advantages over discontinuing it completely. I've seen many patients, particularly on clozapine, who I thought did not benefit very much from it until we discontinued it. Then we realized how much they had benefited from it.”
“The concept of deprescribing should be incorporated into our daily practice with a mindful approach to decisions and have a clear definition in mind about something being inappropriate. Transient side effects are not a good reason for people not to take their antidepressants.”
Expert review synthesizes clinical recommendations for deprescribing psychotropic medications in mood disorders, highlighting practical integration strategies across varied care contexts.
In recent years deprescribing mood disorder medications has attracted increasing attention, and guidance provides suggestions for clinical implementation of deprescribing strategies that have been derived through expert consensus. Summarising and highlighting key recommendations, we discuss their execution in various clinical contexts and discuss their integration into clinical practice.
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Looi et al. (2026) studied this question.
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