What does this research mean for the field?

The cystic fibrosis pancreas undergoes a loss and remodeling of its innervation secondary to early-life exocrine disease, which contributes to impaired islet hormone secretion. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

What question did this study set out to answer?

To determine whether autonomic nervous system degeneration contributes to impaired pancreatic polypeptide and islet hormone secretion in cystic fibrosis.

September 15, 2026Clinical ScienceOpen Access

Structural and functional impact of cystic fibrosis on endocrine pancreatic innervation

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Authors

XSXingshen Sun YYYaling Yi SHShanming Hu

Discussion

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Overview

Translational study demonstrates loss of parasympathetic pancreatic innervation in humans and ferrets with cystic fibrosis, indicating early-life tissue damage drives islet hormone dysfunction.

Key Points

To determine whether autonomic nervous system degeneration contributes to impaired pancreatic polypeptide and islet hormone secretion in cystic fibrosis.
Assessed pancreatic polypeptide (PP) secretion and pancreatic neuronal immunostaining in humans and ferrets with cystic fibrosis.
Evaluated cell-intrinsic hormone secretion using isolated perifused islets from ferrets with cystic fibrosis.
Administered a CFTR modulator to neonatal CFTRG551D homozygous ferrets to delay early exocrine tissue damage and monitor pancreatic neuronal integrity.
Young humans and ferrets with cystic fibrosis exhibited severely impaired PP secretion despite normal islet PP cell counts and intact secretion in perifused isolated islets.
Pan-neuronal staining was virtually absent in human cystic fibrosis pancreata and structurally aberrant in ferrets, with parasympathetic innervation nearly absent in both species.
Early CFTR modulator therapy in CFTRG551D ferrets preserved pancreatic neuronal markers and restored PP secretory responsiveness following oral glucose administration.

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/6aa913909013453be30a1963 https://doi.org/10.1042/cs20260182

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September 15, 2026Clinical ScienceOpen Access

Structural and functional impact of cystic fibrosis on endocrine pancreatic innervation

View Full Paper

Ask AI

Bookmark

Authors

XSXingshen Sun YYYaling Yi SHShanming Hu

Discussion

Member takes

Overview

Translational study demonstrates loss of parasympathetic pancreatic innervation in humans and ferrets with cystic fibrosis, indicating early-life tissue damage drives islet hormone dysfunction.

Key Points

To determine whether autonomic nervous system degeneration contributes to impaired pancreatic polypeptide and islet hormone secretion in cystic fibrosis.
Assessed pancreatic polypeptide (PP) secretion and pancreatic neuronal immunostaining in humans and ferrets with cystic fibrosis.
Evaluated cell-intrinsic hormone secretion using isolated perifused islets from ferrets with cystic fibrosis.
Administered a CFTR modulator to neonatal CFTRG551D homozygous ferrets to delay early exocrine tissue damage and monitor pancreatic neuronal integrity.
Young humans and ferrets with cystic fibrosis exhibited severely impaired PP secretion despite normal islet PP cell counts and intact secretion in perifused isolated islets.
Pan-neuronal staining was virtually absent in human cystic fibrosis pancreata and structurally aberrant in ferrets, with parasympathetic innervation nearly absent in both species.
Early CFTR modulator therapy in CFTRG551D ferrets preserved pancreatic neuronal markers and restored PP secretory responsiveness following oral glucose administration.

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/6aa913909013453be30a1963 https://doi.org/10.1042/cs20260182

View Full Paper

Ask AI

Bookmark