Key result
Serum vitamin D shows no association with platelet function or bleeding severity in primary ITP.
Why the study?
Vitamin D deficiency is associated with autoimmune diseases including ITP and may influence platelet function, which could affect bleeding and thrombotic risk in ITP patients.
Do serum vitamin D levels correlate with platelet function and bleeding severity in patients with primary immune thrombocytopenia?
Cross-Sectional (n=79)
No
Do serum vitamin D levels correlate with platelet function and bleeding severity in patients with primary immune thrombocytopenia?
Serum vitamin D levels do not appear to be the primary driver of platelet function or bleeding phenotype in patients with primary immune thrombocytopenia.
Primary immune thrombocytopenia (ITP) is an autoimmune mediated thrombocytopenia with destruction and impaired production of platelets. Though life-threatening bleeding can occur in ITP, bleeding symptoms are often mild relative to platelet count. ITP is also associated with an increased thromboembolic risk. Variations in platelet function may contribute to the bleeding and thrombotic phenotype of ITP. Vitamin D (VD) deficiency (VDD) has been linked to enhanced platelet function in healthy individuals and patients receiving dual antiplatelet therapy. As VDD is associated with several autoimmune diseases including ITP, we aimed to investigate the influence of serum VD levels on platelet function in ITP. We assessed P-selectin and activated GPIIb/IIIa expression in naïve and stimulated platelets, soluble P-selectin levels, bleeding severity, and mean platelet volume in 79 primary ITP patients from the Vienna ITP Biobank but found no association with VD levels. Thus, low VD levels do not correlate with enhanced platelet function in ITP. Further, bleeding was not associated with VD, adjusting for platelet count. In summary, VD does not seem to be the primary driver of platelet function in ITP.
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Oosterlee et al. (2026) conducted a cross-sectional in Primary immune thrombocytopenia (ITP) (n=79). Serum vitamin D levels was evaluated on Platelet function (P-selectin and activated GPIIb/IIIa expression, soluble P-selectin, mean platelet volume) and bleeding severity. Serum vitamin D levels were not associated with platelet function or bleeding severity in patients with primary immune thrombocytopenia.
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