Key result
Genomic sequencing reveals a pediatric G9P[23] rotavirus strain has entirely porcine origins, indicating interspecies transmission.
Why the study?
The genetic characterization and interspecies transmission dynamics of unusual human rotavirus strains with porcine origin were not well understood.
Case Report (n=1)
No
Identification of a porcine-origin G9P[23] rotavirus strain in a human child provides evidence for porcine-to-human interspecies transmission.
Genomic surveillance of emerging rotavirus strains should continue; leaves open questions on prevalence, transmissibility, and vaccine impact.
An unusual rotavirus strain with the G9P[23] genotype (RVA/Human-wt/THA/KKL-117/2014/G9P[23]) was identified in a stool specimen from a 10-month-old child hospitalized with severe diarrhoea. In this study, we sequenced and characterized the complete genome of strain KKL-117. On full-genomic analysis, strain KKL-117 was found to have the following genotype constellation: G9-P[23]-I5-R1-C1-M1-A8-N1-T1-E1-H1. The non-G/P genotype constellation of this strain (I5-R1-C1-M1-A8-N1-T1-E1-H1) is commonly shared with rotavirus strains from pigs. Furthermore, phylogenetic analysis indicated that each of the 11 genes of strain KKL-117 appeared to be of porcine origin. Our observations provide important insights into the dynamic interactions between human and porcine rotavirus strains.
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Komoto et al. (2017) conducted a case report in Severe diarrhoea (rotavirus infection) (n=1). G9P[23] rotavirus strain (RVA/Human-wt/THA/KKL-117/2014/G9P[23]) was evaluated on Genotype constellation and phylogenetic origin. Genomic analysis of a G9P[23] rotavirus strain from a child with severe diarrhoea revealed that all 11 genes appeared to be of porcine origin, indicating interspecies transmission.
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