What does this research mean for the field?

Standardized clinical documentation of hypoxic-ischemic encephalopathy (HIE) staging is frequently inconsistent, and significant early neurodevelopmental morbidity occurs across all severity stages, including mild HIE. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the clinical profiles, staging documentation consistency, and early neurodevelopmental outcomes in neonates admitted with hypoxic-ischemic encephalopathy at an Australian tertiary perinatal unit.

September 15, 2026Journal of Paediatrics and Child HealthOpen Access

Profile of Neonates Admitted With Hypoxic‐Ischemic Encephalopathy and Early Neurodevelopment Outcomes: A Retrospective Cohort Study

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Authors

VCVisothpong Chhoam NNNicole Ng ARAbdul Razak

Discussion

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Overview

Retrospective cohort study reveals frequent neurodevelopmental delays across all severity levels in neonates with hypoxic-ischemic encephalopathy, highlighting the need for long-term surveillance.

Key Points

To evaluate the clinical profiles, staging documentation consistency, and early neurodevelopmental outcomes in neonates admitted with hypoxic-ischemic encephalopathy at an Australian tertiary perinatal unit.
Retrospective cohort study (2019–2025) of 114 neonates born at ≥ 35 weeks' gestation and admitted with hypoxic-ischemic encephalopathy (HIE) to an Australian tertiary center.
Evaluated documentation of modified Sarnat staging, administration of therapeutic hypothermia, and neonatal survival.
Assessed early neurodevelopmental outcomes at 3–4 months corrected age using standardized developmental testing.
Initial HIE staging documentation was comprehensive in 63.2% (72/114) of infants, while 36.8% (42/114) required retrospective score reconstruction.
Therapeutic hypothermia was administered to 77.1% (27/35) of infants with mild HIE and 89.9% (71/79) with moderate-to-severe HIE; mortality was 0% (0/35) in the mild group versus 20.3% (16/79) in the moderate-to-severe group.
Abnormal neurodevelopmental outcomes at 3–4 months corrected age occurred in 29.6% (8/27) of tested neonates with mild HIE and 59.6% (34/57) of those with moderate-to-severe HIE.

Cite This Study

Chhoam et al. (2026) studied this question.

synapsesocial.com/papers/6aa913f39013453be30a253f https://doi.org/10.1111/jpc.70588

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September 15, 2026Journal of Paediatrics and Child HealthOpen Access

Profile of Neonates Admitted With Hypoxic‐Ischemic Encephalopathy and Early Neurodevelopment Outcomes: A Retrospective Cohort Study

View Full Paper

Ask AI

Bookmark

Authors

VCVisothpong Chhoam NNNicole Ng ARAbdul Razak

Discussion

Member takes

Overview

Retrospective cohort study reveals frequent neurodevelopmental delays across all severity levels in neonates with hypoxic-ischemic encephalopathy, highlighting the need for long-term surveillance.

Key Points

To evaluate the clinical profiles, staging documentation consistency, and early neurodevelopmental outcomes in neonates admitted with hypoxic-ischemic encephalopathy at an Australian tertiary perinatal unit.
Retrospective cohort study (2019–2025) of 114 neonates born at ≥ 35 weeks' gestation and admitted with hypoxic-ischemic encephalopathy (HIE) to an Australian tertiary center.
Evaluated documentation of modified Sarnat staging, administration of therapeutic hypothermia, and neonatal survival.
Assessed early neurodevelopmental outcomes at 3–4 months corrected age using standardized developmental testing.
Initial HIE staging documentation was comprehensive in 63.2% (72/114) of infants, while 36.8% (42/114) required retrospective score reconstruction.
Therapeutic hypothermia was administered to 77.1% (27/35) of infants with mild HIE and 89.9% (71/79) with moderate-to-severe HIE; mortality was 0% (0/35) in the mild group versus 20.3% (16/79) in the moderate-to-severe group.
Abnormal neurodevelopmental outcomes at 3–4 months corrected age occurred in 29.6% (8/27) of tested neonates with mild HIE and 59.6% (34/57) of those with moderate-to-severe HIE.

Cite This Study

Chhoam et al. (2026) studied this question.

synapsesocial.com/papers/6aa913f39013453be30a253f https://doi.org/10.1111/jpc.70588

View Full Paper

Ask AI

Bookmark