Five New 3,4-Seco-Lanostane-type Triterpenoids with Antiproliferative Activity in Human Leukemia Cells Isolated from the Roots of Kadsura coccinea

Five new 3,4-seco-lanostane-type triterpenoids, seco-coccinic acids G-K (1-5), and a known compound, seco-coccinic F, were isolated from the roots of Kadsura coccinea (Lem.) A. C. Sm. Their structures were elucidated by spectroscopic methods, including 2D-NMR and HR-MS techniques. The cell growth inhibitory effects of these compounds were assayed in human leukemia HL-60 cells, and it was found that 1, 5, and 6 showed antiproliferative effects with GI₅₀ values of 28.4, 15.2, and 16.6 µM, respectively.