The cytogenetic analysis of a child with unspecific dysplastic signs revealed the karyotype: 46, XX, del(11) (q21). Two hypotheses could explain the mild phenotypical expression of this deletion: 1) The material of the deficient part of chromosome 11 is genetically inert or redundant (which seems unlikely); 2) “Gene‐dosis‐compensation” occurs for the loss of genes on the deficient part of chromosome 11.
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Faust et al. (1974) studied this question.
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