Key result
Bariatric surgery linked to reduced systemic inflammation and improved pro-angiogenic macrophage precursors at 3 months.
Why the study?
Bariatric surgery reduces cardiometabolic risk and mortality alongside sustained weight loss, but its relationship with obesity-related regenerative cell exhaustion and vessel maintenance required investigation.
Does bariatric surgery improve systemic inflammatory burden and pro-angiogenic macrophage precursor content in subjects with severe obesity?
Observational
Does bariatric surgery improve systemic inflammatory burden and pro-angiogenic macrophage precursor content in subjects with severe obesity?
Bariatric surgery reduces systemic inflammatory burden and improves pro-angiogenic macrophage precursor content at 3 months, potentially reversing cardiovascular risk in severe obesity.
Answers are grounded in this paper and cite their sources.
May signal lower CV risk after bariatric surgery in severe obesity; leaves open translation to clinical outcomes in randomized trials.
Bariatric surgery, in addition to the benefit of sustained weight loss, can also reduce cardiometabolic risk and mortality. Lifelong vessel maintenance is integral to the prevention of cardiovascular disease. Using aldehyde dehydrogenase activity, an intracellular detoxifying enzyme present at high levels within pro-vascular progenitor cells, we observed an association between chronic obesity and "regenerative cell exhaustion" (RCE), a pathology whereby chronic assault on circulating regenerative cell types can result in adverse inflammation and diminished vessel repair. We also describe that, at 3 months following bariatric surgery, systemic inflammatory burden was reduced and pro-angiogenic macrophage precursor content was improved in subjects with severe obesity, suggesting the restoration of a microenvironment to support vessel homeostasis. These data suggest that bariatric surgery may reverse deleterious events that predispose patients with morbid obesity to cardiovascular risk.
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Hess et al. (2020) conducted an observational in Severe obesity. Bariatric surgery was evaluated on Systemic inflammatory burden and pro-angiogenic macrophage precursor content. Bariatric surgery reduced systemic inflammatory burden and improved pro-angiogenic macrophage precursor content at 3 months in subjects with severe obesity.
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