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November 14, 2019HaematologicaOpen Access

High frequency of chronic lymphocytic leukemia-like low-count monoclonal B-cell lymphocytosis in Japanese descendants living in Brazil

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Evaluate the prevalence of chronic lymphocytic leukemia-like low-count monoclonal B-cell lymphocytosis among Japanese descendants residing in Brazil.
Assessed blood samples from Japanese descendants living in Brazil to detect circulating clonal B-cell populations.
Identified immunophenotypic profiles characteristic of chronic lymphocytic leukemia-like low-count monoclonal B-cell lymphocytosis.
Detected an unexpectedly high frequency of chronic lymphocytic leukemia-like low-count monoclonal B-cell lymphocytosis in the cohort.
Demonstrated that Japanese descendants in Brazil exhibit higher rates of clonal B-cell expansions than typically reported for native populations in Japan.

Implication

Cross-sectional analysis reveals elevated chronic lymphocytic leukemia-like monoclonal B-cell lymphocytosis in Japanese descendants, highlighting potential environmental or epigenetic influences.

Abstract

FAPESP (proc 2010/17668-6) and CAPES (scholarship ) from Brazil; RD12/0036/0048, CB16/12/00400 (CIBERONC), PI12/00905-FEDER and PI17/00399-FEDER, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad, (Madrid, Spain and FONDOS FEDER).

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Cite This Study

Moss et al. (2019) studied this question.

synapsesocial.com/papers/6aa91efc81e8d79342fd3144 https://doi.org/10.3324/haematol.2019.230813

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Implication

Cross-sectional analysis reveals elevated chronic lymphocytic leukemia-like monoclonal B-cell lymphocytosis in Japanese descendants, highlighting potential environmental or epigenetic influences.

High frequency of chronic lymphocytic leukemia-like low-count monoclonal B-cell lymphocytosis in Japanese descendants living in Brazil

Key Points

Implication

Abstract

Discussion

Cite This Study

High frequency of chronic lymphocytic leukemia-like low-count monoclonal B-cell lymphocytosis in Japanese descendants living in Brazil

Key Points

Implication

Abstract

Discussion

Cite This Study

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