Stereoselective Total Synthesis of (+)-Varitriol, (−)-Varitriol, 5′-epi-(+)-Varitriol, and 4′-epi-(−)-Varitriol from d -Mannitol

Stereoselective total syntheses of natural (+)-varitriol (1), (-)-varitriol (2), 5'-epi-(+)-varitriol (3), and 4'-epi-(-)-varitriol (4) have been accomplished with use of D-mannitol as a chiral pool material. The Heck reaction was used to assemble the olefinic sugar moiety and the aromatic triflate moiety.