Key result
Age, gender, and smoking linked to variations in plasma extracellular vesicle markers in healthy individuals.
Why the study?
The protein phenotype of extracellular vesicles in plasma may be influenced by demographic factors such as gender, age, and smoking status, affecting their use as diagnostic biomarkers.
Does smoking, age, or gender affect the protein phenotype of extracellular vesicles in plasma in healthy individuals?
Observational (n=161)
Does smoking, age, or gender affect the protein phenotype of extracellular vesicles in plasma in healthy individuals?
Answers are grounded in this paper and cite their sources.
Demographic factors like age, gender, and smoking status influence plasma extracellular vesicle markers, highlighting the need for appropriate demographic matching in EV-based diagnostic studies.
Extracellular vesicles (EVs) are involved in several diseases, which have formed the basis for the potential use of EV analyses in a clinical setting. The protein phenotype of EVs can provide information on the functionality of the vesicles and may be used for identification of disease-related biomarkers. With this extensive study of 161 healthy individuals it was elucidated that certain markers of plasma EVs are influenced by demographic variations such as gender, age and smoking status. When the purpose is to use EVs as a diagnostic tool, it should be emphasized how important it is to choose the correct demographic group when comparing marker levels of plasma EVs.
No takes yet. Share an insight, caveat, or question.
Bæk et al. (2016) conducted an observational in Healthy individuals (n=161). Demographic variations (gender, age, and smoking status) was evaluated on Protein phenotype/markers of plasma extracellular vesicles. Demographic variations such as gender, age, and smoking status influence certain markers of plasma extracellular vesicles in healthy individuals.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: