Key result
Review details hypertriglyceridemia management and risk factors in preterm and critically ill infants.
Why the study?
Preterm and critically ill infants are at risk for hypertriglyceridemia, yet clinicians lack a universally agreed upon definition and evidence-based approach to its management.
This review provides a detailed overview of triglyceride metabolism and practical considerations for managing hypertriglyceridemia in the neonatal population.
May inform hypertriglyceridemia management in preterm infants; leaves open need for prospective validation of thresholds.
Preterm and critically ill infants are at risk for hypertriglyceridemia (HTG). Common risk factors for HTG include prematurity, intravenous lipid emulsion dose and oil composition, reduced lipoprotein lipase activity, fetal growth restriction, sepsis, and renal failure. Despite these risk factors, clinicians lack a universally agreed upon definition for HTG and evidence-based approach to HTG management. This review provides a detailed overview of triglyceride and intravenous lipid emulsion metabolism and how this relates to specific HTG risk factors, along with some practical considerations for managing HTG in the neonatal population.
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Chan et al. (2022) conducted a review in Hypertriglyceridemia. This review details triglyceride metabolism, hypertriglyceridemia risk factors, and practical management considerations for preterm and critically ill infants.
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