Key result
Double-blind placebo-controlled gluten challenges lack standardized vehicle preparation methods for assessing non-celiac gluten sensitivity.
Why the study?
There is no standardized method for the preparation of indistinguishable gluten vehicle and placebo products for double-blind placebo-controlled gluten challenges in non-celiac gluten sensitivity assessment, complicating comparisons across studies.
How can gluten vehicles and placebos be standardized for the assessment of Non-Celiac Gluten Sensitivity?
How can gluten vehicles and placebos be standardized for the assessment of Non-Celiac Gluten Sensitivity?
This review highlights the need for standardized methods to prepare gluten vehicles and placebos to accurately diagnose Non-Celiac Gluten Sensitivity.
Absence of standardized gluten vehicle preparation impairs reliable NCGS diagnosis; leaves open consensus protocols for future double-blind challenges.
Non-celiac gluten sensitivity (NCGS) is a syndrome characterized by gastrointestinal and extraintestinal manifestations triggered after gluten ingestion in the absence of celiac disease and wheat allergy. Because of the lack of biomarkers for NCGS diagnosis, the cornerstone for its assessment is a single- or double-blind placebo-controlled (DBPC) gluten challenge. However, there are some non-standardized points in the diagnostic approach proposed by the experts. This complicate comparisons among the results published by different research groups. The gluten vehicle and placebo must be indistinguishable from each other, which entails sensory and technological evaluations of the designed gluten vehicle and placebo products. At the moment, there is no standardized method for the preparation of the gluten vehicle and placebo for carrying out DBPC gluten challenges for NCGS assessment. This review focuses on the challenges that researchers have to face, either for the development of an accepted gluten vehicle and placebo or for identifying NCGS cases on the basis of DBPC gluten challenges.
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Figueroa-Salcido et al. (2019) conducted a review in Non-celiac gluten sensitivity. Gluten vehicle and placebo was evaluated. There is currently no standardized method for preparing the gluten vehicle and placebo for double-blind placebo-controlled gluten challenges to assess non-celiac gluten sensitivity.
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